2023.01.30 08:26 (prieš 3 m.)
Mitochondria are the most abundant organelles in eggs and in early embryos that generate approximately 90% of reactive oxygen species (ROS), the end products of oxygen metabolism, and convert ROS into an inactive state via antioxidant defense mechanisms. Higher levels of ROS accumulating in mitochondria during multiple physiological conditions contribute to mitochondrial dysfunction and increase in oxidative stress. This, in turn, leads to oxidative damage to DNA and other intra-cellular aberrations, which are similar to the age-related changes. Thus, improving mitochondrial function by supplementing with antioxidants has been proposed as one of the important strategies to enhance reproductive performance. Coenzyme Q10 (CoQ10) is an essential component of the inner mitochondrial membrane. Decrease in CoQ10 level is commonly observed in individuals in late thirties and appears to co-occur with the age-related decline in fertility and increased rate of embryo aneuploidy (genetic abnormality), suggesting a contribution of the reduced expression of CoQ10 to ovarian ageing. In clinical settings, CoQ10 supplementation led to better response to ovulation induction and decreased rates of fetal genetic abnormalities in 35–43-year-old women. In 2018, a randomized controlled study revealed that CoQ10 administration, even in young age group, enhanced ovarian response to stimulation and improved oocyte and embryo quality.
Consumption of 600 mg Co-enzyme Q10 per day for 60 days made a significant contribution to pregnancy rates as well.
